Aruna (Dian Sastrowardoyo) is an epidemiologist but her real passion is eating. She thinks and obsesses about food 24/7. When she is dispatched to investigate curious cases of Avian Flu in several cities in the Indonesian archipelago, she brings along her two best friends, the quirky US-trained chef Bono (Nicholas Saputra), and the impossibly chid food and travel writer Nadezhda (Hannah Al Rashid) to eat along with her. Insights on food, local history, religion and Indonesian politics merge as they find out more that what they bargained for in cities as diverse as Surabaya, Pamekasan (Madura), Pontianak, and Singkawang. During her trip, Aruna accidentally meets her ex-rival and crush, Farish (Oka Antara), which later on she senses something fishy about him.